Aicar Selective Androgen Receptor Modulator Sarm Steroids CAS2627-69-2

Model NO.: 2627-69-2
Trademark: Desen Nutrition
Transport Package: Box-Packed
Specification: 2mg
Origin: China
HS Code: 2500666303
Model NO.: 2627-69-2
Trademark: Desen Nutrition
Transport Package: Box-Packed
Specification: 2mg
Origin: China
HS Code: 2500666303

AICAR Selective Androgen Receptor Modulator Sarm Steroids CAS2627-69-2

 

Basic Infomation:


Acadesine/AICAR Powder CAS:2627-69-2
Alias:AICAR; AICA-RIBOSIDE; AMPK; Z-RIBOSIDE
CAS:2627-69-2
EINECS:220-097-5
Molecular Formula:C9H14N4O5
Molecular Weight:258.23
Apperance: White or off-white powder.

Aicar Introductions:


AICAR is an adenosine analog that selectively activates AMP-activated protein kinase (AMPK). AMPK regulates lipid and glucose metabolism to maintain cellular energy homeostasis (Hardie and Carling).

AICAR can play a hand in boosting these processes because it contains the ability to penetrate cardiac cells and block the production of enzymes tied to regulating glucose intake and energy expulsion. With these regulatory enzymes inhibited, the affected cells can in turn boost the amount of glucose that can be received, and it can also increase its level of energy conversion. Additionally, the peptide's presence has been determined to aid in lowering programmed cell death, a process that is also known as apoptosis.

Functions:


AICAR (AICA-Riboside) strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK (AMP-activated protein kinase), and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase).

 

The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.

 

Specification:

 

Item Specification Result
Appearance White powder Complies
Related substance (HPLC) Total impurity ≤0.5%
Max single impurity ≤0.1%		 0.2%
0.06%
Odor Characteristic Complies
Assay 99% 99.8%
Sieve analysis 100% pass 80 mesh Complies
Loss on Drying
Residue on Ignition		 ≤1.0%
≤1.0%		 0.12%
0.09%
Heavy Metal <10ppm Complies
As <0.1ppm 0.05ppm
Pb <0.1ppm 0.05ppm
Cd <0.1ppm 0.05ppm
Residual Solvents <100ppm Complies
Residual Pesticide Negative Complies
Total Plate Count <1000cfu/g Complies
Yeast & Mold <100cfu/g Complies
E.Coli Negative Complies
Salmonella Negative Complies


 

AICAR Selective Androgen Receptor Modulator Sarm Steroids CAS2627-69-2

 

Basic Infomation:


Acadesine/AICAR Powder CAS:2627-69-2
Alias:AICAR; AICA-RIBOSIDE; AMPK; Z-RIBOSIDE
CAS:2627-69-2
EINECS:220-097-5
Molecular Formula:C9H14N4O5
Molecular Weight:258.23
Apperance: White or off-white powder.

Aicar Introductions:


AICAR is an adenosine analog that selectively activates AMP-activated protein kinase (AMPK). AMPK regulates lipid and glucose metabolism to maintain cellular energy homeostasis (Hardie and Carling).

AICAR can play a hand in boosting these processes because it contains the ability to penetrate cardiac cells and block the production of enzymes tied to regulating glucose intake and energy expulsion. With these regulatory enzymes inhibited, the affected cells can in turn boost the amount of glucose that can be received, and it can also increase its level of energy conversion. Additionally, the peptide's presence has been determined to aid in lowering programmed cell death, a process that is also known as apoptosis.

Functions:


AICAR (AICA-Riboside) strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK (AMP-activated protein kinase), and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase).

 

The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.

 

Specification:

 

Item Specification Result
Appearance White powder Complies
Related substance (HPLC) Total impurity ≤0.5%
Max single impurity ≤0.1%		 0.2%
0.06%
Odor Characteristic Complies
Assay 99% 99.8%
Sieve analysis 100% pass 80 mesh Complies
Loss on Drying
Residue on Ignition		 ≤1.0%
≤1.0%		 0.12%
0.09%
Heavy Metal <10ppm Complies
As <0.1ppm 0.05ppm
Pb <0.1ppm 0.05ppm
Cd <0.1ppm 0.05ppm
Residual Solvents <100ppm Complies
Residual Pesticide Negative Complies
Total Plate Count <1000cfu/g Complies
Yeast & Mold <100cfu/g Complies
E.Coli Negative Complies
Salmonella Negative Complies


 

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