New application of nano-diamond in the field of medical temperature measurement technology

Abstract On August 1st, US local time, researchers at Harvard University published a technical result of using nanodiamond to measure the temperature of a single living cell. The study, published in the latest issue of Nature, shows that temperature measurement technology is supported by synthetic diamonds...
On August 1st, US local time, Harvard researchers published a technical result of using nanodiamonds to measure the temperature of a single living cell. The study, published in the latest issue of Nature, shows how sophisticated the temperature measurement technology is with the support of synthetic nanodiamonds.

Scientists have found that single-atomic impurities in diamond crystals (usually replaced by a nitrogen atom and a vacancy) are very sensitive to temperature changes, and such temperature fluctuations can be a technical obstacle to maintaining quantum bits, but for the medical field. For biological temperature measurement, it is very useful.

In this study at Harvard University, workers placed a 100 nm diamond particle into a human cell and then irradiated the diamond particle with a green laser. Since the laser changes the spin state of the electrons in the impurity, the emitted green laser becomes a red laser after passing through the nanodiamond particles. The degree of laser color change can be used to measure changes in temperature within the body's cells.

The picture shows that the temperature change caused by a gold particle being irradiated by a laser beam is accurately measured by the nanodiamond particles.
Based on this test, the worker tried to put two nano-diamond particles into a human cell, irradiated with two green lasers, and then calculated the degree of change of the emitted red laser. These two experimental comparisons allow workers to measure temperature differences at different locations within the same cell. After that, the researchers placed a nano-diamond particle and a gold particle in the same cell, and irradiated with two green lasers respectively; the heat emitted by the gold particles after the irradiation migrated into the cell, and the temperature change is good. Measured by nanodiamond particles.

With nanodiamond particle technology, scientists can measure temperature fluctuations to 0.05 Kelvin. This result is not the most extreme. The previous in vitro temperature measurement experiment has reached the temperature measurement of 0.0018 Kelvin. Scientists hope to use this technology to achieve the lowest level of measurement accuracy in intracellular temperature measurement.

This high-precision temperature difference measurement technology based on nano-diamond particles can help doctors to distinguish cancer-causing cells in the human body and make medical diagnosis in time. The application prospect of nano-diamond materials is therefore more extensive. (Compiled from "Researchers develop nanodiamond thermometer to take temperature of individual cells"; Translation: Wang Xian)

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