Dicalcium Phosphate, CAS# 17789-77-7, is a inorganic compound manufactured through chemical synthesis, available as WHITE POWDER. Dicalcium Phosphate is widely used as food supplements. It is widely accepted as safe food additive in many countries. Is there some safety and/or health risk about Dicalcium Phosphate that consumers need to know? Let's check out some basic facts about this ingredient. GRAS Exemptions: Yes Generally recognized as safe(GRAS) is a FDA designation that a specific substance or ingredient is generally considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. Dicalcium Phosphate is perfectly safe for using as food additives. Suggested Dosage Ingestion of Dicalcium Phosphate in large quantity may hurt our health, please follow the guideline of using Dicalcium Phosphate: MTDI 70 mg/kg body weight (as P) Special Groups Precaution Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups. There is no evidence that Dicalcium Phosphate could have any negative effects on these vulnerable groups. It should be safe to use Dicalcium Phosphate in food for newborns and pregnant. However, we still recommend consumers to consult professionals before using large quantity of Dicalcium Phosphate for long period in food for newborns or pregnant. General Side Effects No significant side effects reported. The only concern is prolonged using of phosphate salts may upset the balance of phosphates and other chemicals in the body. Reported Health Issues No health issues about Dicalcium Phosphate reported up to now. Related Research 1. Inactivation of transmissible spongiform encephalopathy agents during the manufacture of dicalcium phosphate from bone. [Vet Rec. 2006 Mar 18] Author: Grobben AH, Steele PJ, Somerville RA, Taylor DM. 2. Crystallization of dicalcium phosphate dihydrate with presence of glutamic acid and arginine at 37 °C. [Mater Sci Eng C Mater Biol Appl. 2014 Aug 1] Author: Li C, Ge X, Li G, Bai J, Ding R. 3. Dicalcium phosphate (CaHPO4·2H2O) precipitation through ortho- or meta-phosphoric acid-etching: effects on the durability and nanoleakage/ultra-morphology of resin-dentine interfaces. [J Dent. 2013 Nov] Author: Feitosa VP, Bazzocchi MG, Putignano A, Orsini G, Luzi AL, Sinhoreti MA, Watson TF, Sauro S. See more at: http://www.foodchemadditives.com/side_effects_info/643